The Pignatelli lab is located on the 9th floor of the Neuroscience research building at the Washington University School of Medicine. The lab space consists of ~1,000 square feet, equipped with state-of-the-art computers, as well as a wet lab for solution, brain slice, stereotaxic surgery, histology, optical fiber, electrode preparation and molecular biology.  

While we utilize diverse classical and cutting-edge technical approaches, we are carrying out a hypothesis-driven research with the goal of providing a mechanistic understanding of the fundamental biological questions that we are addressing. Our most commonly used approaches are outlined below. 

Approaches and Techniques

Slice electrophysiology

In vivo electrophysiology

Fiber Photometry


Behavioral assays

Intersectional genetic approaches